The gold standard of scientific evidence

That is the title of my latest article in Pharmaceutical Market Europe. An excerpt is below. Randomised controlled trials (RCTs) are regarded as the gold standard of scientific evidence, and for good reason. By randomizsing a treatment across study arms, RCTs eliminate patient-treamtent selection bias, resulting in reliable causal inference. In contrast, in the real…

More Randomization Problems

Randomized clinical trials (RCTs) are the “gold standard” for medical studies. Nevertheless, even RCTs have their problems. An NBER working paper by Ludwig, Marcotte and Norberg points highlights some of these issues. The authors examine whether or not anti-depressants reduce suicide rates (they find that anti-depressants do reduce suicide rates). Unfortunately, using data from RCTs…