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Sarah Emond on Prescription for Better Access.  “Nothing will have more impact on workers’ comp than significant cuts to Medicaid.” “So one can only assume that we’re not picking flu strains this year.” SLR: Palliative care effectiveness/cost effectiveness NBER: Economics of Artificial Intelligence

More evidence that there are diminishing marginal returns to quality of life gains

Quality-adjusted life years (QALYs) are commonly used to evaluate the impact of new medical technologies on patient mortality and morbidity. However, use of QALYs Many authors have discussed the fact that standard assumptions result in utility functions that are unrealistically linear and separable, overlooking the diminishing marginal utility a fundamental property of utility functions in…

What is Project IDEATE?

How best can you design an outcomes based agreement (OBA)? What are the key factors to consider? Project IDEATE is a “cross-disciplinary collaboration between National Health Service (NHS) Wales, industry and academia” with the aim to develop and refine OBA models. This initiative is described in Burton et al. (2024). What were the key factors…

Can the NIH replace all private sector clinical R&D?

A paper by Proudman et al. (2024) finds that doing so would be extremely expensive. Including all preclinical, clinical and post-approval R&D activities, total annual costs to maintain the average lifecycle level of 49.4 approved drugs across all disease areas during the 2018–22 period was estimated to be $139.6 billion. Including only pre-launch costs, total…

Vaccine choice = more measles infection

Texas is moving to allow for more freedom of choice with respect to receipt of vaccines. The Economist reports: Texas legislators meeting in Austin, the state capital, are debating new laws to relax vaccine rules, urged on by Texans for Vaccine Choice (TFVC). On February 18th activists in “Come and Make Me” shirts took to…

LLM in HEOR: An evaluation framework

Health economics and outcomes research has already started to use AI tools such as large language models (LLM) across a diverse set of study types, including systematic literature reviews (SLR), health economic modelling (HEM) and real-world evidence (RWE). In SLRs, LLMs can assist with abstract and full-text screening, bias assessment, data extraction, and automating meta-analysis…