Unbiased Analysis of Today's Healthcare Issues
Not a surprise, but the study approach used by Kulaja et al. (2022) is interesting. They examine identical twins an examine how early adult exercise habits impact long term health outcomes. The abstract is below. …monozygotic (MZ) twin pairs discordant for health habits provide an interesting natural experiment. Twin pairs discordant for leisure‐time physical activity…
A paper by Birg (2022) aims to examine how mandatory increases in rebates for pharmaceutical products impacts the use of parallel imports. She uses a policy change from 2010 in Germany which mandated increased pharmaceutical rebates to identify the impact of this change. What are parallel imports? Parallel imports are drugs that are imported from…
That is according to an article today from the BBC. NHS leaders in Scotland have discussed abandoning the founding principles of the service by having the wealthy pay for treatment.The discussion of a “two-tier” health service is mentioned in draft minutes of a meeting of Scotland’s NHS leaders in September. They also raise the possibility…
Many studies (e.g., Okui 2020, Le Bon 2014, Blanchflower and Oswald 2009) have claimed that mental health exhibits a U shape where mental health decrease with a nadir at middle age and then increases as people grow into their elderly years. However, a recent study by Dijk and Mierau (2022) finds that mental health may…
At first glance, one may think the answer is no. Randomization should insure that baseline characteristics are balanced across trial arms. In practice, however, sometimes baseline characteristics due differ somewhat by trial arm simply by chance, especially in smaller randomized controlled trials (RCTs). A JAMA Guide to Statistics and Methods by Holmberg et al. 2022…
Impact of elections on health care. “This is our COVID” Are patient satisfaction scores harming patients and physicians? The cost of satisfaction. Proposal for a healthcare minimum wage. Crypto news: Don’t regulate crypto. SBF interview.
Clinical trials have detailed study protocols and are registered on ClinicalTrials.gov. What level of details are needed for real-world data (RWD) analyses that aim to estimate treatment effects? In Europe, the European Medicines Agency (EMA) requires registration of many study protocols using a template for observational post-authorization safety studies (PASS) conducted by marketing authorization holders.…
That is the question Park, Langellier, and Meyers (2022) aim to estimate in their recent Health Services Research publication. The authors use 2015-2017 data from the Centers for Medicare and Medicaid services and control for other differences between integrated and non-integrated Medicare Advantage (MA) plans using state fixed effects and contract random effects. Using this…
Real-world data is becoming increasingly important as the amount of data generation increases as does the speed of data processing. In the US, the 21st Century Cures Act was enacted in December 2016 and mandated that the Food and Drug Administration (FDA) create a framework for evaluating the use of real-world data help support the…
The generic share of total prescriptions dispensed in the US increased from 14% when the Hatch-Waxman legislation was passed [1984] to 42% by 2000 and 92% today. James C. Robinson in JAMA 2022