Should pay toilets be illegal?

At first glance, John Cochrane makes a compelling case that pay toilets should not be illegal. The absence of pay toilets is in fact a delightful encapsulation of so much that is wrong with American economic policy these days. Activists decide free toilets are a human right, and successfully campaign to ban pay toilets. For…

Did your real-world study follow STROBE guidelines?

Is your observational research study following best practices? Is your methodology transparent? To help answer these questions, the Enhancing the QUAlity and Transparency Of health Research (EQUATOR) Network created the STROBE guidelines. The STROBE guidelines–an acronym for The Strengthening the Reporting of Observational Studies in Epidemiology–aim to improve the transparency of the methods behind observational…

When (and how) to use population-adjusted indirect comparisons?

Population-adjusted indirect comparisons (PAICs) include both matching-adjusted indirect comparisons (MAICs) and Simulated treatment comparisons (STCs). The key data requirement for these methods is that they have individual patient data (IPD) from at least one clinical trial. This means the methods are most useful for studied funded by the clinical trial sponsor or when IPD clinical…

Using wastewater to monitor COVID-19

Understanding trends in COVID-19 transmission rates is vital both public health monitoring and policymaking decisions. However, diagnostic capacity may be limited, and test sampling is often non-random, and often COVID-19 cases are not reported when patients have mild or asymptomatic disease. What is the solution? A paper in Nature Biotechnology argues that wastewater testing may…