What is the best way to predict medication adherence? Logistic vs. LASSO vs. random forest

Let’s say you are studying patients taking Drug A for Disease X. Further assume that you want to identify predictors that a patient is adherent to Drug A. Using health insurance claims data, you define your outcome–medication adherence–as whether the patient had proportion of days covered (PDC) is greater than or equal to 80%, the…

Does physician knowledge of patient non-compliance change prescribing behavior in the real world?

This is the topic of a recent publication with co-authors Kata Bognar, Katie Everson, Michelle Brauer, Darius Lakdawalla and Felicia Forma.  The full title is Does knowledge of patient non-compliance change prescribing behavior in the real world? A claims-based analysis of patients with serious mental illness.  The abstract is below, but do read the whole thing…

Modelling medication adherence patterns for patients with serious mental and physical illnesses

Please check out my recent paper titled “Medication Adherence Patterns Among Patients with Multiple Serious Mental and Physical Illnesses” with co-authors Joanna P. MacEwan, Alison R. Silverstein, Darius N. Lakdawalla, Ainslie Hatch and Felicia M. Forma in Advances in Health.   This study is unique because it looks at medication adherence patterns among patients with…

Access to credible information on schizophrenia patients’ medication adherence by prescribers can change their treatment strategies

Below is the abstract for my most recent publication titled “Access to credible information on schizophrenia patients’ medication adherence by prescribers can change their treatment strategies: evidence from an online survey of providers“.  It is work with Suepattra G May, Anshu Shrestha, Charles Ruetsch, Nicole Gerlanc, Felicia Forma, Ainslie Hatch, Darius N Lakdawalla, and Jean-Pierre Lindenmayer.…

Patterns of Adherence to Atypical Antipsychotics

A study titled “Patterns of Adherence to Oral Atypical Antipsychotics Among Patients Diagnosed with Schizophrenia” was just published in the November edition of JMCP.  This is work with co-authors Joanna P. MacEwan, Felicia M. Forma, Jason Shafrin, Ainslie Hatch, Darius N. Lakdawalla, Jean-Pierre Lindenmayer. The abstract is below.  Go check it out! BACKGROUND: Poor medication adherence…

The value of adherence information

A study titled “Estimating the Value of New Technologies That Provide More Accurate Drug Adherence Information to Providers for Their Patients with Schizophrenia” was just published in the November edition of JMCP.  This is work with co-authors Taylor T. Schwartz, Darius N. Lakdawalla, and Felicia M. Forma.  The abstract is below.  Go check it out!  …

Does adherence information affect physician decisions?

According to a recent study of patients with hypertension, the answer is yes. The study by Kronish et al. (2016) used a cluster randomized trial design made up of 24 providers and 100 patients.  Half of the providers were randomized to receive received a report summarizing electronically measured patient adherence to their blood pressure regimen as well as and recommended clinical to…

Can physicians affect medication adherence?

According to a recent study by Koulayev, Simeonova, and Skipper (2016) using data from Denmark, the answer is ‘yes’. Non-compliance with medication therapy remains an unsolved and expensive problem for healthcare systems around the world, yet we know little about the factors that affect a patient’s decision to follow treatment recommendations. In particular, there is…

Do physicians know whether patients are adherent?

Doctors have access to life saving medication for a number of illnesses.  However, the medication only works when patients take the drugs.  Are physicians able to determine which patients are adherent to their medication?  According to an article in JAMA Cardiology, the answer is ‘no’ for cardiology patients. Forty (61%) patients reported rarely or never…