A Generalized Risk Adjusted Cost Effectiveness (GRACE) Economic Model for Measuring the Value of Interventions that Delay Mobility Impairment Across Neurological Conditions

That is the title of a new paper out in Value in Health with co-authors Jaehong Kim, Jacob Fajnor, Kyi-Sin Than, Elizabeth S. Mearns , Stacey L. Kowal, Thomas Majda and Jakub P. Hlávka PhD. The abstract is below. Objectives To quantify how incorporating patient risk preferences and severity adjustments affect the value of a…

Risk aversion estimates for GRACE

Generalized risk-adjusted cost effectiveness (GRACE) aims to incorporate risk preferences into standard cost effectiveness analysis (CEA) methods. While traditional CEA assumes individuals are risk neutral, GRACE allows for risk preferences to influence value. Namely, that health gains in more severely ill health states are valued more than equivalent health gains in better health states. But…

High quality comparative effectiveness research

What are the best practices for conducting comparative effectiveness research in the real-world?  One proposed best practice guildelines are the Good Research for Comparative Effectiveness (GRACE) guidelines.  However, most studies do not follow these guidelines.  A paper by Dreyer, Bryant and Velentgas (2016) assembled 28 observational comparative effectiveness articles published from 2001 to 2010 that compared treatment effectiveness and/or…