Will the UK (finally) increase drug prices?

President Trump’s May 12 Executive Order around Most-Favored-Nation drug pricing argues that countries outside the US need to raise their prices on pharmaceuticals saying that many other countries are “freeloading” and paying less than their share for pharmaceuticals. In response, pharmaceutical companies have increased prices in the UK and even threatened to “walk away” from…

A deeper dive into drug revenue and cost

Many people don’t understand why pharmaceuticals cost so much money. Don’t pharmaceutical companies make a lot of money? The answer is ‘yes’, but only if the drugs are successful. A paper by Wouters et al. (2024) found that: Based on data for 361 of 558 new therapeutic agents approved over the study period (median follow-up…

Impact of financial incentives on the value of the marginal drug

From an interesting review paper in the Journal of Economic Perspectives by Craig Garthwaite: Although research and development investments clearly respond to market opportunities, the exact benefits created by these incremental investments remain unclear. This is largely because the exact marginal products developed in response to these incentives are elusive to identify. Certainly, the amount…

Life sciences companies falling behind?

That is what an analysis from PwC finds, at least with respect to stock market returns. Our PwC equal-weight index of 50 pharma companies analyzes the sector’s total shareholder returns performance relative to the S&P 500 Equal Weighted Index. From 2018 through November 2024, the PwC pharma index returned 7.6% to shareholders, compared with more…

How would the inclusion of specialty drugs impact CPI-Rx?

The Bureau of Labor Statistics’ (BLS’) Prescription Drug Consumer Price Index (CPI‐Rx) looks at price changes for drugs dispensed at outpatient retail pharmacies. However, many pharmaceuticals–especially infusions and injections–are administered at physician offices or hospitals. How would including physician-administered drugs impact the CPI-Rx? That is the question a paper by Hicks, Berndt and Frank (2024)…

Will IRA increase CMS drug spending?

Potentially so, argues Adam Fein of Drug Channels. There are two mechanisms for this. First, for drugs not covered in the maximum fair price negotiations, Fein argues that drugs with high list prices and large rebates would lead to more net savings compared to drugs with lower list price and rebates in part because in…

EMA and delays in drug launch

For patients with serious illnesses, timeline access to efficacious medications is paramount. The European Medicines Agency (EMA) was created in part to help expedite drug approvals and insure these products are save and effective. As stated in a paper by Grünwald and Stargardt (2024): The EMA [European Medicines Agency] was founded in 1995 primarily to…