Pharma pipeline as of 2023
Some stats from Citeline’s Pharma R&D Annual Report 2023. And by company sorted by pipeline size as of January 2023:
Category: HC Statistics
Excess mortality among Black Americans
A paper by Caraballo et al. (2023) published today uses CDC data to measure excess mortality among Black Americans between 1999-2020. They find that: From 1999 to 2011, the age-adjusted excess mortality rate declined from 404 to 211 excess deaths per 100 000 individuals among Black males (P for trend <.001). However, the rate plateaued from…
How long were US schools closed during COVID-19 compared to other countries?
Results below from UNESCO data. Presented without commentary. HT: Marginal Revolution
Impact of poverty on mortality
A paper by Brady et al. (2023) aims to measure this relationship in the US. They use data from the 1997-2019 Panel Study of Income Dynamics (PSID) data merged with the Cross-National Equivalent File. The data were validated with information from the National Death Index. The authors adjust for self-reported health, demographics, comorbidities and a…
How have US cost-effectiveness thresholds changed over time?
That is the questions Peter Neumann and David Kim (2023) answer in their JAMA research letter published today. They use 1990-2021 data from the Tufts Medical Center CEA Registry. The results are summarized in the graphs below. First, we see the use of a explicit cost effectiveness threshold increasing over time, from only 45% of…
Pediatric mortality rates rising
Some troubling statistics published recently by Woolf et al. (2023) using CDC WONDER data: Between 2019 and 2020, the all-cause mortality rate for ages 1 to 19 years increased by 10.7%, and it increased by an additional 8.3% between 2020 and 202…These increases, the largest in decades, followed a period of great progress in reducing…
Office of Generic Drugs 2022 Annual Report
FDA’s Office of Generic Drugs issued their 2022 Annual Report. Generic drugs play a vital role in saving patients and payers money. To give an example, pregabalin capsules cost $450 for a 30-day supply during the end of its market exclusivity period, but priced dropped to $23 (a 95% decrease) during the first 12 months…
Will half the world be overweight?
A study by the World Obesity Foundation predicts that more than half the global population will be living with overweight and obesity within 12 years if prevention, treatment and support do not improve. The report also predicts that the global economic burden of overweight and obesity will be $4.32 trillion or approximately 2.9% of global…
The cancer tax
An ambitious paper by Chen et al. (2023) published last week aim to estimate the economic burden of cancer across 204 countries between 2020 and 2050 . The authors find that cancer’s economic burden is equivalent to an annual tax of 0.55% of global GDP. The full results are below. The estimated global economic cost…
Single Arm Trials for FDA Drug Approvals in Oncology
These are becoming increasingly common. Agrawal et al. (2022) use data between 2002-2021, and found that FDA approved: …176 new malignant hematology and oncology indications based on single-arm trials, including 116 accelerated approvals (AAs) and 60 traditional approvals. Overall, 87 approvals (49%) were for new molecular entities or original biologics and 89 (51%) were supplemental…