Unbiased Analysis of Today's Healthcare Issues
Clinical trials are short, but the benefits of many drugs lasts months or even years beyond the duration of these trials. To quantify the full costs and benefits of a treatment over time (for instance as used for HTA purposes), one must extrapolate this clinical benefits. Commonly, this extrapolation is done using a parametric function…
Clinical trials are typically of (relatively) short duration, but innovative treatments may impact patient survival over multiple years. Health economists and outcomes researchers often are faced with the challenge of extrapolating clinical trial survival curves to estimate long-term survival gains for the typical patient. These estimates may be done parameterically (e.g., exponential, Weibull, Gompertz, log-logistic,…