Local instrumental variables (LIV) vs. two-stage least squares (2SLS)

An interesting recent paper by Moler-Zapata, Grieve, Basu, and O’Neill (2023) compares local instrumental variables (LIV) with two-stage least squares (2SLS) to IV. Local instrumental variable (LIV) approaches use continuous/multi-valued instrumental variables (IV) to generate consistent estimates of average treatment effects (ATEs) and Conditional Average Treatment Effects (CATEs). There is little evidence on how LIV…

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Which HVBP components matter for patients choosing a hospital? Conflict of interest for RVU determination. How are payers de-risking cell and gene therapy cost (hint: stop-loss insurance) Over-the-counter birth control pill approved. ICER to advise CMS on MFP calculation?

The Largest Insurance Expansion in History

That is the title of an important paper by Jonathan Gruber, Mengyun Lin & Junjian Yi. The abstract is below: The New Cooperative Medical Scheme (NCMS) rolled out in China from 2003-2008 provided insurance to 800 million rural Chinese. We combine aggregate mortality data with individual survey data, and identify the impact of the NCMS…

The Economics of Generic Drugs

One piece of good news for consumers is that generic prices are falling. However, generic prices may be falling so much that drug shortages are occurring (which is not a good thing). Data from a working paper by Sardella (2023) finds a dramatic drop in generic prices in recent years. The authors claim that shortages…

A Decade of Health Innovation: The Impact of New Medicines on Patient Health and the Implications for NICE’s Size of Benefit Multiplier

That is the title of a study published today with co-authors Sabiha Quddus, Moises Marin, and Dennis Scanlon PhD. The abstract is below. ObjectiveTo estimate the incremental health benefits of pharmaceutical innovations approved between 2011-2021 and the share that would surpass the National Institute for Health and Care Excellence (NICE) ‘size of benefit’ decision weight…